DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 (IC50=0.57 μM). DS18561882 exhibits a good oral pharmacokinetic profile.

Product information

CAS Number: 2227149-22-4

Molecular Weight: 608.63

Formula: C28H31F3N4O6S

Chemical Name: N-(4-{8-[(3S)-3,4-dimethylpiperazin-1-yl]-7-methyl-5-oxo-1H,2H,3H,4H,5H-chromeno[3,4-c]pyridine-3-carbonyl}-2-(trifluoromethoxy)phenyl)methanesulfonamide

Smiles: CN1CCN(C[C@@H]1C)C1=CC=C2C3CCN(CC=3C(=O)OC2=C1C)C(=O)C1=CC(OC(F)(F)F)=C(C=C1)NS(C)(=O)=O

InChiKey: OQKAKSSZSQPTDZ-INIZCTEOSA-N

InChi: InChI=1S/C28H31F3N4O6S/c1-16-14-34(12-11-33(16)3)23-8-6-20-19-9-10-35(15-21(19)27(37)40-25(20)17(23)2)26(36)18-5-7-22(32-42(4,38)39)24(13-18)41-28(29,30)31/h5-8,13,16,32H,9-12,14-15H2,1-4H3/t16-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (410.76 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DS18561882 (0-150 nM) gives the lowest GI50 value (140 nM) against the MDA-MB-231 cell line.

In Vivo:

DS18561882 (oral administration; 30, 100 or 300 mg/kg; twice daily) inhibits tumor growth inhibition with a dose-dependent manner, the tumor is completely inhibited (TGI: 67%) at the dose of 300 mg/kg in mice. DS18561882 (oral administration; 10, 30, 100, or 300 mg/kg) has a good oral pharmacokinetic profile, including ACU (64.6, 264, 726 μg.h/ml ); Cmax (11.4, 56.5, 90.1 μg/ml); t1/2 (2.21, 2.16, 2.32 hours) for 30 mg/kg; 100mg/kg; 200 mg/kg, respectively. DS18561882 is suspended in a 0.5% (w/v) methyl cellulose 400 solution in this article.

Products are for research use only. Not for human use.